Detection of ubiquitinated huntingtin species in intracellular aggregates
نویسندگان
چکیده
منابع مشابه
Detection of ubiquitinated huntingtin species in intracellular aggregates
Protein conformation diseases, including polyglutamine (polyQ) diseases, result from the accumulation and aggregation of misfolded proteins. Huntington's disease (HD) is one of nine diseases caused by an expanded polyQ repeat within the affected protein and is hallmarked by intracellular inclusion bodies composed of aggregated N-terminal huntingtin (Htt) fragments and other sequestered proteins...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2015
ISSN: 1662-5099
DOI: 10.3389/fnmol.2015.00001